Functional reorganization induced by endovascular embolization of a cerebral AVM

R S Marshall; L Hacein-Bey; W L Young; J Pile-Spellman; S Das; G Perera; J P Mohr

doi:10.1002/(SICI)1097-0193(1996)4:3<168::AID-HBM2>3.0.CO;2-1

Functional reorganization induced by endovascular embolization of a cerebral AVM

Hum Brain Mapp. 1996;4(3):168-73. doi: 10.1002/(SICI)1097-0193(1996)4:3<168::AID-HBM2>3.0.CO;2-1.

Authors

R S Marshall¹, L Hacein-Bey, W L Young, J Pile-Spellman, S Das, G Perera, J P Mohr

Affiliation

¹ Department of Neurology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032, USA.

PMID: 20408196
DOI: 10.1002/(SICI)1097-0193(1996)4:3<168::AID-HBM2>3.0.CO;2-1

Abstract

We mapped motor function in a patient with a cerebral arteriovenous malformation (AVM) before and after treatment with endovascular embolization. Functional activation using technetium-99m-hexamethylpropyleneamine single photon emission tomography (99mTc-HMPAO-SPECT) demonstrated a redistribution of regional cerebral blood flow (rCBF) that correlated with clinical improvement. Intravascular feeding artery pressure measurements, serial angiography, and challenge with a pharmacological vasodilator enabled us to explore possible mechanisms of functional reorganization.