Abstract
Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Cell Line
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Cell Line, Tumor
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Cell Survival / drug effects
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Cyclooxygenase 2 / immunology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Humans
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Lipopolysaccharides / immunology
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Macrophages / drug effects*
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Macrophages / immunology
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Molecular Structure
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Nitric Oxide Synthase / immunology
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Lipopolysaccharides
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Nitric Oxide Synthase
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Cyclooxygenase 2