Abstract
The yeast culture, Rhodotorula mucilaginosa (ATCC 20129) transformed flutamide (1) to three metabolites: 4-nitro-3-(trifluoromethyl)aniline (2), 2-methyl-N-[4-amino-3-(trifloromethyl)phenyl]propanamide (3) and N-[4-amino-3-(trifluoromethyl)phenyl]acetamide (4). The structures were established by spectroscopic methods.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Hormonal / chemistry
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Antineoplastic Agents, Hormonal / metabolism*
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Flutamide / chemistry
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Flutamide / metabolism*
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Humans
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Molecular Structure
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Rhodotorula / chemistry
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Rhodotorula / metabolism*
Substances
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Antineoplastic Agents, Hormonal
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Flutamide