Abstract
It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Bone and Bones / drug effects*
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Fracture Fixation
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Fracture Healing / drug effects*
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Humans
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Osseointegration / drug effects*
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Prosthesis Failure
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Spinal Fusion
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Tendons / drug effects*
Substances
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Anti-Inflammatory Agents, Non-Steroidal