Preterm infants with bronchopulmonary dysplasia (BPD) have cardiorespiratory compromise that prolongs the transition time from gavage to nipple feeding. Heart rate variability (HRV) provides an indirect measure of the autonomic nervous system's influence on heart rate and cardiorespiratory stability. The purpose of this case study was to describe HRV responses of three preterm infants with BPD during the transition from gavage to nipple feeding. The infants responded to nipple feeding with increases in sympathetic influence on heart rate, and the increase continued in the 10-minute postfeeding. The infants were capable of balancing sympathetic and parasympathetic influences on heart rate related to the work of feeding.