Ovarian stimulation retards postimplantation development and alters global gene expression profile of blastocysts in mouse

Xinyan Zhang; Li Wang; Xiuli Li; Ke Li; Jing Fang; Yuanqing Yao

doi:10.1016/j.fertnstert.2010.03.018

Ovarian stimulation retards postimplantation development and alters global gene expression profile of blastocysts in mouse

Fertil Steril. 2010 May 15;93(8):2770-3. doi: 10.1016/j.fertnstert.2010.03.018.

Authors

Xinyan Zhang¹, Li Wang, Xiuli Li, Ke Li, Jing Fang, Yuanqing Yao

Affiliation

¹ Department of Obstetrics and Gynecology, General Hospital of the People's Liberation Army, Beijing, People's Republic of China.

PMID: 20434150
DOI: 10.1016/j.fertnstert.2010.03.018

Abstract

This study compares the quality, developmental capacity and global gene expression profile of embryos generated from superovulated and natural cycles. We found that ovarian stimulation impaired quality of blastocysts (cell number: 68.9 +/- 6.9 vs. 76.8 +/- 7.9; diameter of blastocysts: 145.3 +/- 76.9 microm vs. 152.6 +/- 65.5 microm), fetus development (rate of development to term: 45.5% vs. 69.1%; weight of 18.5-dpc fetuses: 1.23 +/- 0.03 g vs. 1.34 +/- 0.03 g) and caused 92 genes differentially expressed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blastocyst / physiology*
Embryo Implantation
Embryo, Mammalian
Embryonic Development*
Gene Expression Profiling*
Mice
Oligonucleotide Array Sequence Analysis
Ovulation Induction*