Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study

Br J Psychiatry. 2010 May;196(5):412-3. doi: 10.1192/bjp.bp.109.070441.

Abstract

We applied voxel-based morphometry to high-resolution magnetic resonance images of 99 participants with schizophrenia. Voxel-wise correlations with a score of auditory hallucination severity identified areas in the left and right superior temporal cortex (including Heschl's gyrus), left supramarginal/angular gyrus, left postcentral gyrus and left posterior cingulate cortex. This study extends previous region-of-interest studies demonstrating main effects of auditory hallucinations related to modality-specific superior temporal areas including primary and secondary auditory cortices.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Auditory Cortex / pathology
  • Brain / pathology*
  • Brain Mapping / methods
  • Female
  • Hallucinations / pathology*
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Schizophrenia / pathology*
  • Temporal Lobe / pathology
  • Young Adult