Abstract
Within the context of experimental pharmacology, some criteria are discussed for estimating the potential of natural products with possible pharmacological activity for the treatment of hypertension. This disorder has great epidemiological impact in Colombia as well as elsewhere. Discovery of these products can be accomplished by use of accessible pharmacological tests such as the following: developing models of arterial hypertension in the laboratory rat, in vitro tests, in vivo tests and microscopic analysis. Suitable protocols associated with these techniques can capture valuable information about possible effects on hypertension during the evaluation phase of a natural product.
MeSH terms
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Animals
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Antihypertensive Agents / pharmacology*
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Antihypertensive Agents / therapeutic use
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Aorta / drug effects
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Biological Products / pharmacology*
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Biological Products / therapeutic use
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Blood Pressure / drug effects*
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Disease Models, Animal
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Drug Evaluation, Preclinical / methods*
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Hypertension / chemically induced
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Hypertension / drug therapy
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Hypertension / genetics
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Medicine, Traditional
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Models, Animal
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NG-Nitroarginine Methyl Ester / toxicity
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Nitric Oxide Donors / pharmacology
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Nitric Oxide Donors / therapeutic use
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Phytotherapy
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Plant Preparations / isolation & purification
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Plant Preparations / pharmacology
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Plant Preparations / therapeutic use
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Rats
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Rats, Inbred Dahl
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Rats, Inbred SHR
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Renin-Angiotensin System / drug effects
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Vascular Resistance / drug effects
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Vasodilator Agents / pharmacology
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Vasodilator Agents / therapeutic use
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Ventricular Remodeling / drug effects
Substances
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Antihypertensive Agents
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Biological Products
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Nitric Oxide Donors
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Plant Preparations
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Vasodilator Agents
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NG-Nitroarginine Methyl Ester