The impact of CCL3L1 copy number in an HIV-1-infected white population

AIDS. 2010 Jun 19;24(10):1589-91. doi: 10.1097/QAD.0b013e3283398294.

Abstract

We examined the effect of CCL3L1 gene copy number on disease progression in a North American white cohort of HIV-1-infected individuals. Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors. These findings underscore the heterogeneity of factors involved with long-term nonprogression when comparing cohorts of varying ethnic backgrounds.

MeSH terms

  • CD4 Lymphocyte Count
  • Chemokines, CC / genetics*
  • Disease Progression
  • Gene Dosage
  • HIV Infections / genetics*
  • HIV Infections / immunology
  • HIV-1 / genetics*
  • Humans
  • Viral Load
  • White People / genetics*

Substances

  • CCL3L1 protein, human
  • Chemokines, CC