Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma

J Infect Dis. 2010 Jun 15;201(12):1919-22. doi: 10.1086/652869.

Abstract

Antibody responses against lytic and latent Kaposi sarcoma (KS)-associated herpesvirus antigens were investigated in patients with KS, multicentric Castleman disease (MCD), and primary effusion lymphoma. Antibodies against the lytic antigen K8.1 were 5-fold higher in patients with MCD than those with KS, whereas antibodies to the sum of latent antigens v-cyclin and LANA were 27-fold higher in patients with KS, compared with patients with MCD (P < 001). The sum of anti-v-cyclin and anti-LANA antibody titers discriminated patients with KS from those with MCD and KS with 93% sensitivity and 83% specificity. These results suggest that antibody responses to lytic and latent KS-associated herpesvirus antigens differ in these diseases.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Antigens, Viral / immunology*
  • Castleman Disease / diagnosis
  • Castleman Disease / immunology*
  • Herpesvirus 8, Human / immunology*
  • Humans
  • Lymphoma, Primary Effusion / diagnosis
  • Lymphoma, Primary Effusion / immunology*
  • Sarcoma, Kaposi / diagnosis
  • Sarcoma, Kaposi / immunology*
  • Sensitivity and Specificity
  • Serologic Tests / methods
  • Virology / methods*

Substances

  • Antibodies, Viral
  • Antigens, Viral