The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients

Clin Endocrinol (Oxf). 2010 May;72(5):709-15. doi: 10.1111/j.1365-2265.2009.03700.x.

Abstract

Context: The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4.

Design: Randomized, double-blind, cross-over intervention study.

Setting: NIH clinical center.

Patients: Ten thyroidectomized patients.

Interventions: Study participants were treated with L-T3 or L-T4 with a target TSH >or= 0.5 <or= 1.5 mU/l for at least 30 days before undergoing inpatient testing. Following testing, subjects crossed-over according to the same scheme.

Main outcome measures: Area under the serum concentration-time curve of TSH from 0 to 60 min (AUC(0-60)) and peak TSH serum concentration (C(max)) following thyrotropin-releasing hormone (TRH) stimulation test, total L-T4 and L-T3 dose (mcg/kg), and L-T4/L-T3 ratio.

Results: No difference was observed for time 0 TSH values between L-T3 and L-T4 replacement phases (1.48 +/- 0.77 vs. 1.21 +/- 0.62 mU/l, P = 0.293) at average daily doses of 40.3 +/- 11.3 mcg L-T3 and 115.2 +/- 38.5 mcg L-T4, L-T3: L-T4 ratio 0.36 +/- 0.06. TRH stimulation test resulted in similar L-T3 vs. L-T4 TSH responses with AUC(0-60) of 326.1 (95% CI 232.6-457.1) and 247.1 (95% CI 153.8-397.1) mU* min/l (P = 0.285); and C(max) of 6.83 (95% CI 4.88-9.55) and 5.23 (95% CI 3.31-8.3) mU/l (P = 0.383).

Conclusions: This is the first study addressing the equivalency between L-T3 and L-T4 therapy measured by baseline and TRH-stimulated TSH. The therapeutic substitution of L-T3 for L-T4 was achieved at approximately 1:3 ratio.

Trial registration: ClinicalTrials.gov NCT00106119.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Area Under Curve
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Hormone Replacement Therapy*
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / drug therapy*
  • Hypothyroidism / surgery
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Therapeutic Equivalency
  • Thyroid Function Tests
  • Thyroidectomy
  • Thyrotropin / blood
  • Thyroxine / pharmacokinetics
  • Thyroxine / therapeutic use*
  • Treatment Outcome
  • Triiodothyronine / pharmacokinetics
  • Triiodothyronine / therapeutic use*

Substances

  • Triiodothyronine
  • Thyrotropin
  • Thyroxine

Associated data

  • ClinicalTrials.gov/NCT00106119