Treatment of skin cancers in epidermolysis bullosa

Supriya S Venugopal; Dédée F Murrell

doi:10.1016/j.det.2010.01.009

Treatment of skin cancers in epidermolysis bullosa

Dermatol Clin. 2010 Apr;28(2):283-7, ix-x. doi: 10.1016/j.det.2010.01.009.

Authors

Supriya S Venugopal¹, Dédée F Murrell

Affiliation

¹ Department of Dermatology, St George Hospital, University of New South Wales, Kogarah, Sydney, NSW, Australia.

PMID: 20447493
DOI: 10.1016/j.det.2010.01.009

Abstract

Squamous cell carcinomas (SCCs) are highly aggressive in patients with epidermolysis bullosa (EB). Non-ultraviolet-related SCCs are the leading cause of death in patients with recessive dystrophic EB, particularly recessive dystrophic EB-generalized severe subtype (RDEB-GS). The mechanism of SCC development in patients with RDEB continues to be investigated and several theories have been reported in the literature.

Publication types

Review

MeSH terms

Biopsy
Carcinoma, Squamous Cell / complications*
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / therapy*
Epidermolysis Bullosa / complications*
Epidermolysis Bullosa / pathology
Humans
Skin Neoplasms / complications*
Skin Neoplasms / pathology
Skin Neoplasms / therapy*