Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+)

Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. doi: 10.1039/b923688k. Epub 2010 Jan 9.

Abstract

The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cations / chemistry
  • Cations / metabolism
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Conformation
  • Muramidase / chemistry
  • Muramidase / metabolism*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism*
  • Protein Binding
  • Protein Conformation
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / metabolism*
  • Rhenium / chemistry
  • Rhenium / metabolism*

Substances

  • Cations
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Rhenium
  • hen egg lysozyme
  • Muramidase