A new phosphonate pendant-armed cross-bridged tetraamine chelator accelerates copper(ii) binding for radiopharmaceutical applications

Dalton Trans. 2010 Feb 21;39(7):1699-701. doi: 10.1039/b920871b. Epub 2009 Dec 15.

Abstract

A phosphonate pendant-armed cross-bridged cyclam chelator has been synthesized, complexed to Cu(ii), radiolabeled with (64)Cu under mild conditions, and its biodistribution studied.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amines / chemistry*
  • Binding Sites
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacokinetics*
  • Copper / chemistry*
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Structure
  • Organophosphonates / chemistry*
  • Radioisotopes / chemistry
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacokinetics*
  • Stereoisomerism

Substances

  • Amines
  • Chelating Agents
  • Organophosphonates
  • Radioisotopes
  • Radiopharmaceuticals
  • Copper