Biodegradable therapeutic MOFs for the delivery of bioactive molecules

Chem Commun (Camb). 2010 Jul 7;46(25):4526-8. doi: 10.1039/c001181a. Epub 2010 May 13.

Abstract

A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Drug Delivery Systems*
  • Ferric Compounds / chemistry
  • Ferric Compounds / metabolism*
  • Ferric Compounds / therapeutic use*
  • Iron / chemistry*
  • Models, Molecular
  • Niacin / chemistry*
  • Temperature

Substances

  • Ferric Compounds
  • Niacin
  • Iron