Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole

Chi-Un Pae; Alberto Chiesa; Alessandro Serretti

doi:10.1016/j.psychres.2010.04.017

Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole

Psychiatry Res. 2010 Jul 30;178(2):430-2. doi: 10.1016/j.psychres.2010.04.017. Epub 2010 May 14.

Authors

Chi-Un Pae¹, Alberto Chiesa, Alessandro Serretti

Affiliation

¹ Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Bucheon, Kyonggi-Do, Republic of Korea. [email protected]

PMID: 20471098
DOI: 10.1016/j.psychres.2010.04.017

Abstract

We investigated possible influences of 3 single nucleotide polymorphisms in the d-amino acid oxidase activator (rs2391191, rs947267, rs3918342) on clinical outcomes and side effects in 86 Korean schizophrenia patients treated with aripiprazole for 8weeks, finding that individuals carrying rs2391191 A allele had significantly lower brief psychiatric rating scale scores than subjects carrying the G allele at each time point. Further research is needed to determine the role of DAOA on the response to antipsychotics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antipsychotic Agents / therapeutic use
Aripiprazole
Brief Psychiatric Rating Scale
Carrier Proteins / genetics*
Female
Humans
Intracellular Signaling Peptides and Proteins
Korea
Male
Neuropsychological Tests
Pharmacogenetics*
Piperazines / therapeutic use
Polymorphism, Single Nucleotide / genetics*
Psychiatric Status Rating Scales
Quinolones / therapeutic use
Schizophrenia / drug therapy
Schizophrenia / genetics*
Time Factors
Treatment Outcome

Substances

Antipsychotic Agents
Carrier Proteins
DAOA protein, human
Intracellular Signaling Peptides and Proteins
Piperazines
Quinolones
Aripiprazole