Arthrobacter endo-beta-N-acetylglucosaminidase shows transglycosylation activity on complex-type N-glycan oxazolines: one-pot conversion of ribonuclease B to sialylated ribonuclease C

Chembiochem. 2010 Jul 5;11(10):1350-5. doi: 10.1002/cbic.201000242.

Abstract

Asparagine-linked glycosylation is a major form of posttranslational modifications, which plays important roles in protein folding, intracellular signaling, and a number of other biological recognition events [1]. Glycoproteins are often characterized by their structural micro-heterogeneity where different glycoforms have the same polypeptide backbone but differ in the pendant oligosaccharides. Of particular interest are the findings that subtle difference in the attached glycans can have a significant impact on the biological functions of a given glycoprotein [2, 3]. The urgent need of pure glycoforms for functional studies and biomedical applications has stimulated a great interest in exploring new methods for making homogeneous glycoproteins [4]. Major advances include the application of native chemical ligation and expressed protein ligation for constructing full-size glycoproteins [–7], chemoselective ligation to introduce homogeneous glycans [8], and the engineering of yeast glycosylation pathways to produce single glycoforms [9]. Yet another interesting advance in the field is the endoglycosidase-catalyzed transglycosylation for glycosylation engineering and glycoprotein synthesis [–16].

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Arthrobacter / enzymology*
  • Carbohydrate Sequence
  • Endoribonucleases / metabolism*
  • Glycosylation
  • Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase / metabolism*
  • Molecular Sequence Data
  • Oxazoles / chemistry*
  • Ribonucleases / metabolism*
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Oxazoles
  • Endoribonucleases
  • Ribonucleases
  • ribonuclease B
  • ribonuclease C
  • Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase