Bis(7)-tacrine derivatives as multitarget-directed ligands: Focus on anticholinesterase and antiamyloid activities

ChemMedChem. 2010 Aug 2;5(8):1215-20. doi: 10.1002/cmdc.201000086.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / chemistry*
  • Acetylcholinesterase / metabolism
  • Amyloid / chemistry*
  • Amyloid / metabolism
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid Precursor Protein Secretases / metabolism
  • Aspartic Acid Endopeptidases / antagonists & inhibitors
  • Aspartic Acid Endopeptidases / metabolism
  • Binding Sites
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / pharmacology
  • Computer Simulation
  • Drug Design
  • Humans
  • Ligands
  • Tacrine / analogs & derivatives*
  • Tacrine / chemical synthesis
  • Tacrine / chemistry
  • Tacrine / pharmacology

Substances

  • 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine
  • Amyloid
  • Cholinesterase Inhibitors
  • Ligands
  • Tacrine
  • Acetylcholinesterase
  • Amyloid Precursor Protein Secretases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human