Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294

Emmanuel O Carneiro; Carolina H Andrade; Rodolpho C Braga; Andréa C B Tôrres; Rosângela O Alves; Luciano M Lião; Carlos A M Fraga; Eliezer J Barreiro; Valéria de Oliveira

doi:10.1016/j.bmcl.2010.04.073

Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3734-6. doi: 10.1016/j.bmcl.2010.04.073. Epub 2010 Apr 21.

Authors

Emmanuel O Carneiro¹, Carolina H Andrade, Rodolpho C Braga, Andréa C B Tôrres, Rosângela O Alves, Luciano M Lião, Carlos A M Fraga, Eliezer J Barreiro, Valéria de Oliveira

Affiliation

¹ Laboratório de Bioconversão, Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil.

PMID: 20488703
DOI: 10.1016/j.bmcl.2010.04.073

Abstract

A new bioactive compound of the N-acylhydrazone class, LASSBio-294, was shown to produce a cardioinotropic effect and vasodilation. In this study, we report the structure-based drug metabolism prediction, biosynthesis and identification of the major mammalian metabolite of LASSBio-294.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Beauveria / metabolism
Cardiotonic Agents / metabolism*
Dogs
Hydrazones / metabolism*
Magnetic Resonance Spectroscopy
Molecular Structure
Thiophenes / metabolism*
Vasodilation / drug effects*

Substances

Cardiotonic Agents
Hydrazones
LASSBio 294
Thiophenes