Abstract
In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.
MeSH terms
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Alkaloids / chemical synthesis
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Alkaloids / chemistry*
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Alkaloids / toxicity
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Animals
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / toxicity
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Cell Line, Tumor
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Cytotoxins / chemical synthesis
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Cytotoxins / chemistry*
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Cytotoxins / toxicity
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Drug Screening Assays, Antitumor
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Erythrocytes / drug effects
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Humans
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Mice
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Microbial Sensitivity Tests
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Pseudoalteromonas / chemistry*
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Pyrroles / chemical synthesis
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Pyrroles / chemistry
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Pyrroles / toxicity
Substances
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Alkaloids
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Anti-Infective Agents
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Cytotoxins
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Pyrroles
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BE 18591