Palladium nanoparticle catalyzed Hiyama coupling reaction of benzyl halides

J Org Chem. 2010 Jun 18;75(12):4296-9. doi: 10.1021/jo1003373.

Abstract

An efficient Hiyama coupling reaction between benzylic halide and aryltrialkoxysilane using Pd nanoparticles has been developed. This procedure accommodates various functional groups to yield a diverse range of diarylmethanes which are ubiquitous units of natural products and pharmaceuticals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzyl Compounds / chemistry*
  • Catalysis
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Organosilicon Compounds / chemistry
  • Palladium / chemistry*

Substances

  • Benzyl Compounds
  • Organosilicon Compounds
  • phenyltrimethoxysilane
  • Palladium
  • benzyl chloride
  • benzyl bromide