Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties

Alla A Kicha; Natalia V Ivanchina; Trinh T T Huong; Anatoly I Kalinovsky; Pavel S Dmitrenok; Sergey N Fedorov; Sergey A Dyshlovoy; Pham Q Long; Valentin A Stonik

doi:10.1016/j.bmcl.2010.04.005

Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3826-30. doi: 10.1016/j.bmcl.2010.04.005. Epub 2010 Apr 9.

Authors

Alla A Kicha¹, Natalia V Ivanchina, Trinh T T Huong, Anatoly I Kalinovsky, Pavel S Dmitrenok, Sergey N Fedorov, Sergey A Dyshlovoy, Pham Q Long, Valentin A Stonik

Affiliation

¹ Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.

PMID: 20493687
DOI: 10.1016/j.bmcl.2010.04.005

Abstract

New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification*
Cell Line, Tumor
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
NF-kappa B / genetics
Saponins / isolation & purification
Saponins / pharmacology*
Starfish / chemistry*
Transcription Factor AP-1 / genetics
Transcriptional Activation / drug effects
Tumor Suppressor Protein p53 / genetics

Substances

Antineoplastic Agents
NF-kappa B
Saponins
Transcription Factor AP-1
Tumor Suppressor Protein p53
archasteroside A
archasteroside B
regularoside A