Abstract
Phosphate-dependent glutaminase activity in spleen, kidney, brain and liver is increased after tumor cell inoculation and this activity gradually increases with the progression of the tumor. The increase in enzyme activity in the liver is significant. Studies of the response of liver glutaminase after Cu-ATP treatment reveals that Cu-ATP is capable of reducing the high glutaminase level in subjects with malignant tumors to the normal level.
MeSH terms
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Adenosine Triphosphate / therapeutic use*
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Animals
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Brain / enzymology
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Carcinoma, Ehrlich Tumor / drug therapy
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Carcinoma, Ehrlich Tumor / enzymology*
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Carcinoma, Ehrlich Tumor / pathology
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Cell Division / drug effects
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Glutaminase / analysis*
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Glutaminase / antagonists & inhibitors
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Kidney / enzymology
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Liver / drug effects
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Liver / enzymology*
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Mice
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Spleen / enzymology
Substances
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copper adenosine triphosphate
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Adenosine Triphosphate
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Glutaminase