Abstract
Acute kidney injury is common in critically ill patients, with an incidence of 20% to 30%. It has been associated with increased mortality, hospital length of stay, and total cost. A number of strategies may be beneficial in identifying at-risk patients. In addition, using preventive measures and avoiding nephrotoxic medications are paramount in reducing the overall incidence. Although multifactorial, drug-induced acute kidney injury may account for up to 25% of all cases of acute kidney injury in this population. This review focuses on the mechanisms of drug-induced acute kidney injury in critically ill adults and offers preventive strategies when appropriate.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / diagnosis
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Acute Kidney Injury / prevention & control*
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Adult
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Aminoglycosides / adverse effects
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Amphotericin B / adverse effects
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Angiotensin Receptor Antagonists
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Angiotensin-Converting Enzyme Inhibitors / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Antifungal Agents / adverse effects
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Calcineurin Inhibitors
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Contrast Media / adverse effects
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Critical Care / methods*
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Critical Illness
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Cyclooxygenase Inhibitors / adverse effects
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Decision Support Systems, Clinical
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Drug-Related Side Effects and Adverse Reactions / diagnosis
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Drug-Related Side Effects and Adverse Reactions / etiology
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Drug-Related Side Effects and Adverse Reactions / prevention & control
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Humans
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Medical Order Entry Systems
Substances
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Aminoglycosides
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Angiotensin Receptor Antagonists
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Angiotensin-Converting Enzyme Inhibitors
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Anti-Inflammatory Agents, Non-Steroidal
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Antifungal Agents
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Calcineurin Inhibitors
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Contrast Media
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Cyclooxygenase Inhibitors
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Amphotericin B