MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3

Br J Haematol. 2010 Jul;150(2):237-9. doi: 10.1111/j.1365-2141.2010.08185.x. Epub 2010 Apr 28.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Biomarkers, Tumor / metabolism*
  • Cell Cycle Proteins
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Imidazoles / pharmacology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Nuclear Proteins / metabolism*
  • Piperazines / pharmacology*
  • Proto-Oncogene Proteins / metabolism*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • Imidazoles
  • MDM4 protein, human
  • Nuclear Proteins
  • Piperazines
  • Proto-Oncogene Proteins
  • nutlin 3