Abstract
Dedifferentiated chondrosarcomas are highly malignant tumors characterized by conventional low-grade chondrosarcoma with abrupt transition to foci that have dedifferentiated into a higher-grade noncartilaginous more aggressive sarcoma. The dedifferentiated component, an osteosarcoma or fibrosarcoma, determines the prognosis. Its identification is key for management. A diagnosis of dedifferentiated chondrosarcoma should be suggested by the presence of "tumoral dimorphism" with cartilaginous component and aggressive lytic component invading adjacent soft tissues.
MeSH terms
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Aged
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Bone Marrow / diagnostic imaging
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Bone Marrow / pathology
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Bone Neoplasms / diagnosis*
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Bone Neoplasms / diagnostic imaging
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Bone Neoplasms / pathology
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Cartilage / diagnostic imaging
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Cartilage / pathology
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Cell Dedifferentiation
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Chondrosarcoma / diagnosis*
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Chondrosarcoma / diagnostic imaging
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Chondrosarcoma / pathology
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Female
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Femur / diagnostic imaging
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Femur / pathology
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Fibrosarcoma / diagnosis
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Fibrosarcoma / diagnostic imaging
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Fibrosarcoma / pathology
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neoplasm Invasiveness
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Osteolysis / diagnosis
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Osteolysis / diagnostic imaging
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Osteolysis / pathology
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Osteosarcoma / diagnosis
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Osteosarcoma / diagnostic imaging
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Osteosarcoma / pathology
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Prognosis
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Tibia / diagnostic imaging
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Tibia / pathology
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Tomography, X-Ray Computed