Muir-Torre syndrome associated with alpha 1-antitrypsin deficiency and cutaneous vasculitis. Report of a case with exacerbation of a cutaneous neoplasm during immunosuppressive therapy

J Guitart; S T McGillis; W F Bergfeld; R J Tuthill; P L Bailin; C Camisa

doi:10.1016/0190-9622(91)70137-q

Muir-Torre syndrome associated with alpha 1-antitrypsin deficiency and cutaneous vasculitis. Report of a case with exacerbation of a cutaneous neoplasm during immunosuppressive therapy

J Am Acad Dermatol. 1991 May;24(5 Pt 2):875-7. doi: 10.1016/0190-9622(91)70137-q.

Authors

J Guitart¹, S T McGillis, W F Bergfeld, R J Tuthill, P L Bailin, C Camisa

Affiliation

¹ Department of Dermatology, Cleveland Clinic Foundation, Ohio.

PMID: 2050856
DOI: 10.1016/0190-9622(91)70137-q

Abstract

We describe a patient with both Muir-Torre syndrome and alpha 1-antitrypsin deficiency. A keratoacanthoma developed after immunosuppressive therapy for necrotizing vasculitis. To our knowledge, this is the first reported case of Muir-Torre syndrome associated with alpha 1-antitrypsin deficiency.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / pathology*
Adenoma / pathology
Adult
Carcinoma, Squamous Cell / pathology
Cyclophosphamide / therapeutic use
Face*
Facial Neoplasms / pathology
Humans
Keratoacanthoma / pathology*
Male
Neoplasm Invasiveness
Neoplasms, Multiple Primary / pathology*
Sebaceous Gland Neoplasms / pathology
Sigmoid Neoplasms / pathology*
Skin / blood supply*
Skin Diseases / pathology*
Syndrome
Vasculitis / drug therapy
Vasculitis / pathology*
alpha 1-Antitrypsin Deficiency*

Substances

Cyclophosphamide