Cytotoxic activity of trijugin-type limonoids from Cipadessa baccifera

Planta Med. 2010 Nov;76(16):1907-10. doi: 10.1055/s-0030-1249979. Epub 2010 May 27.

Abstract

Two new trijugin-type limonoids, cipatrijugins E and F (1 and 2), together with the known cipatrijugins A and D (3-4), were isolated from the stem bark of Cipadessa baccifera. All structures were elucidated by spectroscopic analysis. The in vitro cytotoxicity of compounds 1-4 was also tested. Compound 1 showed significant in vitro cytotoxicity against MCF-7, SW480, HL-60, and SMMC-7721 cells, with IC(50) values of 5.0, 6.6, 4.5, and 21.6 µM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Cell Line, Tumor
  • Humans
  • Limonins / isolation & purification
  • Limonins / pharmacology
  • Limonins / therapeutic use
  • Meliaceae / chemistry*
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Phytotherapy
  • Plant Bark
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Plant Stems

Substances

  • Antineoplastic Agents, Phytogenic
  • Limonins
  • Plant Extracts