Abstract
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Macrolides / chemistry*
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Macrolides / isolation & purification
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Macrolides / pharmacology
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Molecular Conformation
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology
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Stereoisomerism
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Structure-Activity Relationship
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Ultraviolet Rays*
Substances
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Macrolides
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Pyrones
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apoptolidin A
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apoptolidin G