Use of combined liothyronine and thyroxine therapy for consumptive hypothyroidism associated with hepatic haemangiomas in infancy

Catherine Peters; Shirley Langham; Primus E Mullis; Mehul T Dattani

doi:10.1159/000281884

Use of combined liothyronine and thyroxine therapy for consumptive hypothyroidism associated with hepatic haemangiomas in infancy

Horm Res Paediatr. 2010;74(2):149-52. doi: 10.1159/000281884. Epub 2010 Jun 3.

Authors

Catherine Peters¹, Shirley Langham, Primus E Mullis, Mehul T Dattani

Affiliation

¹ Department of Paediatric Endocrinology, Great Ormond Street Hospital and Institute for Child Health, London, UK.

PMID: 20516650
DOI: 10.1159/000281884

Abstract

Hepatic haemiangiomas in infancy are rare. An association with hypothyroidism has been previously reported and is believed to be secondary to the conversion of thyroxine (fT4) to biologically inactive reverse triiodothyronine (rT3) by type 3 iodothyronine deiodinase (D3). We report a case that responded well to the combined use of liothyronine and thyroxine therapy.

Publication types

Case Reports

MeSH terms

Hemangioma / complications*
Hemangioma / drug therapy
Humans
Hypothyroidism / complications*
Hypothyroidism / drug therapy*
Infant
Iodide Peroxidase / metabolism
Liver Neoplasms / complications*
Liver Neoplasms / drug therapy
Male
Thyroxine / therapeutic use*
Triiodothyronine / therapeutic use*
Triiodothyronine, Reverse / metabolism

Substances

Triiodothyronine
Triiodothyronine, Reverse
Iodide Peroxidase
Thyroxine