The Chronic Pain Acceptance Questionnaire (CPAQ) measures acceptance of pain. Besides previous promising results on the contribution of pain acceptance to physical and psychosocial pain adjustment, recent findings have raised doubts on the validity of the scale. This study explores the psychometric properties of the Italian version of the CPAQ. A total of 120 patients with chronic pain completed the CPAQ and measures of depression, anxiety, pain-related anxiety, functional status, and perceived health status. Internal consistency was satisfactory, and factorial analyses yielded a 2-factor solution, but each CPAQ dimension showed a different contribution to the criterion variables.