Abstract
MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the gonads and tissues of neuroectodermal origin. It also identifies an exon encoding 42 amino acids that is alternatively spliced in murine, but not human testis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular
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Cosmids
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Exons
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Gene Expression
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Guanine Nucleotide Exchange Factors
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Humans
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Kinetics
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Male
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Mice
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Molecular Sequence Data
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Organ Specificity
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Polymerase Chain Reaction / methods
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Protein-Tyrosine Kinases / genetics*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogenes*
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RNA Splicing
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RNA, Messenger / genetics
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Testis / physiology
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X Chromosome*
Substances
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Guanine Nucleotide Exchange Factors
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MAS1 protein, human
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MCF2 protein, human
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Mcf2 protein, mouse
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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RNA, Messenger
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Protein-Tyrosine Kinases