[Bone marrow transplantation in congenital defects of immunity]

Pediatr Med Chir. 1991 Jan-Feb;13(1):27-30.
[Article in Italian]

Abstract

BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.

Publication types

  • English Abstract

MeSH terms

  • Bone Marrow Transplantation* / immunology
  • Bone Marrow Transplantation* / methods
  • Child
  • Child, Preschool
  • Europe
  • HLA Antigens / immunology
  • Histocompatibility Testing
  • Humans
  • Immunity, Cellular / immunology
  • Immunologic Deficiency Syndromes / immunology
  • Immunologic Deficiency Syndromes / mortality
  • Immunologic Deficiency Syndromes / therapy*

Substances

  • HLA Antigens