Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs

J Med Chem. 2010 Sep 23;53(18):6539-49. doi: 10.1021/jm901869w.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allosteric Regulation
  • Animals
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Drug Resistance, Neoplasm / drug effects*
  • E2F1 Transcription Factor / biosynthesis
  • E2F1 Transcription Factor / genetics
  • ErbB Receptors / antagonists & inhibitors
  • Gene Silencing
  • Histone Deacetylase Inhibitors / chemistry
  • Histone Deacetylase Inhibitors / pharmacology
  • Humans
  • Oligodeoxyribonucleotides, Antisense / chemistry
  • Oligodeoxyribonucleotides, Antisense / pharmacology
  • Peptides / chemistry
  • Peptides / pharmacology
  • Protein Conformation
  • Protein Kinase C / antagonists & inhibitors
  • RNA, Small Interfering / genetics
  • Thymidylate Synthase / antagonists & inhibitors
  • Thymidylate Synthase / biosynthesis
  • Thymidylate Synthase / physiology*

Substances

  • Antineoplastic Agents
  • E2F1 Transcription Factor
  • Histone Deacetylase Inhibitors
  • Oligodeoxyribonucleotides, Antisense
  • Peptides
  • RNA, Small Interfering
  • Thymidylate Synthase
  • ErbB Receptors
  • Protein Kinase C
  • Cyclin-Dependent Kinases