Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

Karem Shanab; Eva Schirmer; Heike Knafl; Eva Wulz; Wolfgang Holzer; Helmut Spreitzer; Peter Schmidt; Babette Aicher; Gilbert Müller; Eckhard Günther

doi:10.1016/j.bmcl.2010.05.003

Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3950-2. doi: 10.1016/j.bmcl.2010.05.003. Epub 2010 May 7.

Authors

Karem Shanab¹, Eva Schirmer, Heike Knafl, Eva Wulz, Wolfgang Holzer, Helmut Spreitzer, Peter Schmidt, Babette Aicher, Gilbert Müller, Eckhard Günther

Affiliation

¹ Department of Drug and Natural Product Synthesis, University of Vienna, Austria.

PMID: 20537894
DOI: 10.1016/j.bmcl.2010.05.003

Abstract

A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Molecular Structure
Naphthoquinones / chemical synthesis
Naphthoquinones / chemistry
Naphthoquinones / pharmacology*
Pyrroles / chemical synthesis
Pyrroles / chemistry
Pyrroles / pharmacology*
Stereoisomerism
Structure-Activity Relationship

Substances

Antineoplastic Agents
Naphthoquinones
Pyrroles