Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits

Sangtae Oh; Byong-Gon Park; Jungyeob Ham; Seokjoon Lee

doi:10.1016/j.bmcl.2010.05.044

Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4206-9. doi: 10.1016/j.bmcl.2010.05.044. Epub 2010 May 19.

Authors

Sangtae Oh¹, Byong-Gon Park, Jungyeob Ham, Seokjoon Lee

Affiliation

¹ Department of Basic Science and Physiology, Kwandong University College of Medicine, Gangneung 210-701, Republic of Korea.

PMID: 20541402
DOI: 10.1016/j.bmcl.2010.05.044

Abstract

We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetone / analogs & derivatives*
Acetone / chemistry
Acetone / pharmacology
Animals
Basilar Artery / drug effects
Basilar Artery / physiology
Marine Biology*
Rabbits
Vasodilator Agents / chemical synthesis*
Vasodilator Agents / pharmacology

Substances

Vasodilator Agents
Acetone