Abstract
Yersinia pestis, the etiologic agent of plague, has only recently evolved from Yersinia pseudotuberculosis. hfq deletion caused severe growth restriction at 37 degrees C in Y. pestis but not in Y. pseudotuberculosis. Strains from all epidemic plague biovars were similarly affected, implicating Hfq, and likely small RNAs (sRNAs), in the unique biology of the plague bacillus.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Gene Deletion
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Host Factor 1 Protein / genetics
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Host Factor 1 Protein / metabolism*
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Molecular Chaperones / genetics
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Molecular Chaperones / metabolism*
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RNA, Bacterial / metabolism
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Temperature
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Yersinia pestis / enzymology*
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Yersinia pestis / growth & development*
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Yersinia pseudotuberculosis / enzymology*
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Yersinia pseudotuberculosis / growth & development*
Substances
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Bacterial Proteins
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Host Factor 1 Protein
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Molecular Chaperones
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RNA, Bacterial