Abstract
The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Basic-Leucine Zipper Transcription Factors / chemistry*
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Basic-Leucine Zipper Transcription Factors / metabolism*
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DNA / chemistry
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DNA / metabolism*
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DNA, Mitochondrial / chemistry
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DNA, Mitochondrial / metabolism
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Humans
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Mitochondria / chemistry
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Mitochondria / metabolism
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Mitochondrial Proteins
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Models, Molecular
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Protein Conformation
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Tandem Repeat Sequences*
Substances
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Basic-Leucine Zipper Transcription Factors
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DNA, Mitochondrial
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MTERF1 protein, human
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Mitochondrial Proteins
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DNA