Abstract
A new 1-azaanthraquinone, named laoticuzanone A (1), and a synthetically known 3-methyl-1H-1-azaanthracene-2,9,10-trione (2), together with four known compounds, Griffithazanone A (3), methyl sinapate (4), methyl p-coumarate (5), and p-hydroxyphenylethyl p-coumarate (6) were isolated from the stems of Goniothalamus laoticus. Their structures were established on the basis of spectroscopic data as well as comparisons with the previous literature data. Compound 1 showed the highest cytotoxicity against KB and HeLa cells with IC(50) values of 0.68 and 0.50 μg/ml, respectively.
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Anthraquinones / therapeutic use*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Female
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Goniothalamus / chemistry*
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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KB Cells
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Molecular Structure
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Mouth Neoplasms / drug therapy*
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Stems
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Uterine Cervical Neoplasms / drug therapy*
Substances
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Anthraquinones
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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laoticuzanone A