Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE

Rina Aharoni; Raya Eilam; Ariel Stock; Anya Vainshtein; Elias Shezen; Hilah Gal; Nir Friedman; Ruth Arnon

doi:10.1016/j.jneuroim.2010.04.022

Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE

J Neuroimmunol. 2010 Aug 25;225(1-2):100-11. doi: 10.1016/j.jneuroim.2010.04.022.

Authors

Rina Aharoni¹, Raya Eilam, Ariel Stock, Anya Vainshtein, Elias Shezen, Hilah Gal, Nir Friedman, Ruth Arnon

Affiliation

¹ The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

PMID: 20554028
DOI: 10.1016/j.jneuroim.2010.04.022

Abstract

The aim of this study was to identify cell populations relevant to pathogenesis and repair within the injured CNS in mice that recovered from experimental autoimmune encephalomyelitis (EAE). We demonstrate that in two EAE models, with either relapsing-remitting or chronic course, T-cells and resident activated microglia manifested extensive IL-17 expression, with apparent localization within regions of myelin loss. In mice treated with glatiramer acetate (GA, Copaxone), even when treatment started after disease exacerbation, CNS inflammation and Th-17 occurrence were drastically reduced, with parallel elevation in T-regulatory cells, indicating the immunomodulatory therapeutic consequences of GA treatment in situ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Central Nervous System / drug effects
Central Nervous System / pathology
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental* / drug therapy
Encephalomyelitis, Autoimmune, Experimental* / immunology
Encephalomyelitis, Autoimmune, Experimental* / pathology
Glatiramer Acetate
Immunosuppressive Agents / therapeutic use*
Inflammatory Bowel Diseases / drug therapy
Inflammatory Bowel Diseases / immunology
Interleukin-17 / genetics
Interleukin-17 / metabolism*
Mice
Mice, Inbred C57BL
Multiple Sclerosis, Relapsing-Remitting* / drug therapy
Multiple Sclerosis, Relapsing-Remitting* / immunology
Multiple Sclerosis, Relapsing-Remitting* / pathology
Myelin Proteolipid Protein / immunology
Peptide Fragments / immunology
Peptides / therapeutic use*
Spinal Cord / pathology
Statistics as Topic
T-Lymphocytes, Regulatory / drug effects*

Substances

Immunosuppressive Agents
Interleukin-17
Myelin Proteolipid Protein
Peptide Fragments
Peptides
myelin proteolipid protein (139-151)
Glatiramer Acetate