Abstract
We report a patient with M2 acute non-lymphocytic leukemia and a complex karyotype: 47,XY,t(5;7)(q34;q21), +8. After chemotherapy with Daunomycin and Arabinosyl Cytosine, a complete remission was reached, but two months later he relapsed and died because of sepsis. Only 5 other cases with translocations involving chromosomes 5 and 7 have been described, but with different breakpoints. Several genes related to cell proliferation and maturation have been identified on the long arms of chromosomes 5 and 7. The possible involvement of specific genes located at or very close to the breakpoints is hypothesized.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Amsacrine / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Chromosome Aberrations / genetics*
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Chromosome Disorders
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Chromosomes, Human, Pair 5 / metabolism
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Chromosomes, Human, Pair 7 / metabolism
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Chromosomes, Human, Pair 8 / metabolism
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Cytarabine / administration & dosage
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Daunorubicin / administration & dosage
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Humans
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Karyotyping
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Leukemia, Myeloid, Acute / drug therapy
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Leukemia, Myeloid, Acute / genetics*
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Male
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Mitoxantrone / administration & dosage
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Remission Induction
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Translocation, Genetic / genetics*
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Trisomy
Substances
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Amsacrine
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Cytarabine
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Mitoxantrone
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Daunorubicin