[Pathophysiology of immune thrombocytopenia]

S Audia; B Lorcerie; B Godeau; B Bonnotte

doi:10.1016/j.revmed.2009.05.017

[Pathophysiology of immune thrombocytopenia]

Rev Med Interne. 2011 Jun;32(6):350-7. doi: 10.1016/j.revmed.2009.05.017. Epub 2010 Jun 16.

[Article in French]

Authors

S Audia¹, B Lorcerie, B Godeau, B Bonnotte

Affiliation

¹ Service de médecine interne et immunologie clinique, centre de compétence des cytopénies auto-immunes de Bourgogne Franche-Comté, hôpital du Bocage, CHU de Dijon, 2 boulevard Maréchal-de-Lattre-de-Tassigny, Dijon, France. [email protected]

PMID: 20557985
DOI: 10.1016/j.revmed.2009.05.017

Abstract

Immune thrombocytopenia is an autoimmune disease characterized by a peripheral destruction of platelets. B lymphocytes play a key role but pathogenesis is more complex, involving humoral and cellular immunity associated with an inappropriate platelet production. In this article, we review the different pathogenic pathways, leading to new therapeutic strategies.

Publication types

English Abstract

MeSH terms

Autoimmune Diseases / physiopathology*
Genetic Predisposition to Disease
Humans
Thrombocytopenia / genetics
Thrombocytopenia / immunology*
Thrombocytopenia / physiopathology*