Abstract
The human and simian immunodeficiency viruses contain small open reading frames known as vpr and vpx. These genes encode proteins that are highly related both at the amino acid level and functionally, although key differences do exist. This review describes the main functions ascribed to Vpr and Vpx in the context of both viral replication and modulation of host cell biology.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Apoptosis
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Cell Cycle
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DNA Damage
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Host-Pathogen Interactions*
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Humans
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Simian Immunodeficiency Virus / metabolism
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Simian Immunodeficiency Virus / pathogenicity
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Simian Immunodeficiency Virus / physiology
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Viral Regulatory and Accessory Proteins / metabolism*
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vpr Gene Products, Human Immunodeficiency Virus / chemistry
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vpr Gene Products, Human Immunodeficiency Virus / metabolism*
Substances
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VPX protein, Human immunodeficiency virus 2
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Viral Regulatory and Accessory Proteins
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vpr Gene Products, Human Immunodeficiency Virus