Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway

Julie Daoust; Angelo Fontana; Catherine E Merchant; Nicole J de Voogd; Brian O Patrick; Timothy J Kieffer; Raymond J Andersen

doi:10.1021/ol101151f

Ansellone A, a sesterterpenoid isolated from the nudibranch Cadlina luteromarginata and the sponge Phorbas sp., activates the cAMP signaling pathway

Org Lett. 2010 Jul 16;12(14):3208-11. doi: 10.1021/ol101151f.

Authors

Julie Daoust¹, Angelo Fontana, Catherine E Merchant, Nicole J de Voogd, Brian O Patrick, Timothy J Kieffer, Raymond J Andersen

Affiliation

¹ Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.

PMID: 20560657
DOI: 10.1021/ol101151f

Abstract

Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new "ansellane" sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cyclic AMP / metabolism*
Gastropoda / chemistry*
Porifera / chemistry*
Sesterterpenes / isolation & purification*
Sesterterpenes / pharmacology*
Signal Transduction / drug effects*

Substances

Sesterterpenes
ansellone A
Cyclic AMP