Abstract
Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Amides / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Aspergillus fumigatus / drug effects
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Candida albicans / drug effects
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Fungal Proteins / antagonists & inhibitors
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Fungal Proteins / metabolism
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Microbial Sensitivity Tests
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Pyridines / chemistry*
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Quinolines / chemistry*
Substances
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Amides
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Antifungal Agents
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Fungal Proteins
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Pyridines
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Quinolines
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quinoline
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pyridine