Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Richard Williams; Ya Zhou; Colleen M Niswender; Qingwei Luo; P Jeffrey Conn; Craig W Lindsley; Corey R Hopkins

doi:10.1021/cn9000318

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

ACS Chem Neurosci. 2010 Jun 16;1(6):411-419. doi: 10.1021/cn9000318.

Authors

Richard Williams¹, Ya Zhou, Colleen M Niswender, Qingwei Luo, P Jeffrey Conn, Craig W Lindsley, Corey R Hopkins

Affiliation

¹ Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.

Abstract

Grants and funding