A novel, air-stable phosphine ligand for the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of chloro arenes

J Org Chem. 2010 Aug 6;75(15):5320-2. doi: 10.1021/jo100643j.

Abstract

A novel, air-stable phosphine ligand, prepared from readily available 2-bromonitrobenzene and vinylmagnesium bromide, combines with Pd(CH(3)CN)(2)Cl(2) to afford an effective catalyst for Suzuki-Miyaura cross-coupling of aryl, heteroaryl, and allyl chlorides with phenylboronic acid.