Abstract
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase.
Copyright (c) 2010 Wiley Periodicals, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aminoacyltransferases / antagonists & inhibitors
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Aminoacyltransferases / chemistry
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Aminoacyltransferases / metabolism*
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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Cysteine Endopeptidases / chemistry
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Cysteine Endopeptidases / metabolism*
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Drug Resistance, Bacterial / drug effects
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Drug Resistance, Bacterial / physiology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Gram-Positive Bacteria / enzymology*
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Substrate Specificity / drug effects
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Substrate Specificity / physiology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Enzyme Inhibitors
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Aminoacyltransferases
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Cysteine Endopeptidases