Abstract
Onionin A (1), a new, stable, sulfur-containing compound, was isolated from acetone extracts of bulbs of onion (Allium cepa), and its structure was characterized as 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophen-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis. This compound showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages.
MeSH terms
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Allium / chemistry*
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Antigens, CD / drug effects
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Antigens, Differentiation, Myelomonocytic / drug effects
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CD163 Antigen
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Humans
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Japan
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Macrophages / drug effects*
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Onions / chemistry*
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Receptors, Cell Surface / drug effects
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Sulfoxides / chemistry
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Sulfoxides / isolation & purification*
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Sulfoxides / pharmacology*
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Thiophenes / chemistry
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Thiophenes / isolation & purification*
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Thiophenes / pharmacology*
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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CD163 Antigen
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Receptors, Cell Surface
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Sulfoxides
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Thiophenes
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onionin A