Abstract
The liver is a large abdominal organ in the right hypondrium. Because of its anatomical situation, it is near many abdominal PTVs as well as some lower thoracic PVTs. The liver could also be at the same time the target (for irradiation of liver metastases or primary liver tumours) and organ at risk (OAR). Radiation-induced liver disease (RILD) is radiobiologically the normal tissue complication probability (NTCP), i.e., the clinical event limiting the total dose that could be delivered. This review describes radiobiological criteria justifying the NTCP data, and recommendations for conformal 3D radiotherapy and stereotactic liver irradiation.
Copyright (c) 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
MeSH terms
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Cholesterol / metabolism
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Glucose / metabolism
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Hepatic Veins / anatomy & histology
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Hepatic Veins / radiation effects
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Humans
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Lipids / physiology
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Liver / anatomy & histology
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Liver / physiology
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Liver / radiation effects*
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Liver Neoplasms / radiotherapy
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Liver Neoplasms / secondary
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Neoplasm Metastasis / radiotherapy
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Portal Vein / anatomy & histology
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Portal Vein / radiation effects
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Proteins / metabolism
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Radiation Injuries / diagnostic imaging
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Radiation Injuries / epidemiology*
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Radiation Tolerance*
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Radionuclide Imaging
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Radiosurgery / adverse effects
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Radiotherapy / adverse effects*
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Radiotherapy / methods
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Radiotherapy Dosage
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Radiotherapy, Conformal / adverse effects
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Radiotherapy, Conformal / methods
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Vena Cava, Inferior / anatomy & histology
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Vena Cava, Inferior / radiation effects
Substances
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Lipids
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Proteins
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Cholesterol
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Glucose